After a goalless first half, Cristiano Ronaldo scored two quick goals to secure the win in Turin, which leaves the Bianconeri just one victory from retaining their crown.
Juventus ended a three-match winless run thanks to Ronaldo's second-half brace that moves them eight points clear of second-placed Inter Milan with four games remaining.
Ronaldo's first goal of the night saw him become the fastest player in recent history to reach 50 Serie A goals, doing so in just 61 games. "It means nothing unless the objective is achieved", Sarri said.
Join us for all the build-up and action as it happens from tonight's top of the table showdown, as Juventus and Lazio, Cristiano Ronaldo and Ciro Immobile, go head-to-head. "As for Paulo Dybala, we are discussing a renewal with his entourage, he is a very important player and can give us so much more in future".
Cristiano Ronaldo insisted that while records are nice, the most important thing is for defending champions Juventus to succeed following his historic outing in Serie A.
The 35-year-old also became the first player to bag 50 goals in the Premier League, La Liga and now in Serie A.
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Lazio are seated at the fourth place now in the league standings with 69 points.
Alex Sandro, who saved Juve in their 3-3 draw with Sassuolo last time out, headed versus the post from Matthijs de Ligt's cross in the 11 th minute.
Immobile converted the penalty himself and Szczesny denied Lazio an equaliser when he palmed away a Sergej Milinkovic-Savic free kick which was heading for the top corner.
"As I've always said, talking about an opportunity to win is like a chance to score a goal".
Ronaldo stepped up to slot in on 51 minutes and added a second after a Luiz Felipe blunder allowed Dybala to gain possession with the Argentine powering up the pitch, before teeing up the Portuguese to finish off.
Ronaldo nearly made it three but his header came back off the crossbar, and Lazio found a way back into the game with seven minutes to go.